Abiotic stress of ambient cold temperature regulates the host receptivity to pathogens by cell surfaced sialic acids.
Identifieur interne : 000C03 ( Main/Exploration ); précédent : 000C02; suivant : 000C04Abiotic stress of ambient cold temperature regulates the host receptivity to pathogens by cell surfaced sialic acids.
Auteurs : Seong-Cheol Moon [Corée du Sud] ; Su-Yeon Joo [Corée du Sud] ; Tae-Wook Chung [Corée du Sud] ; Hee-Jung Choi [Corée du Sud] ; Mi-Ju Park [Corée du Sud] ; Hee-Jin Choi [Corée du Sud] ; Sung-Jin Bae [Corée du Sud] ; Keuk-Jun Kim [Corée du Sud] ; Cheorl-Ho Kim [Corée du Sud] ; Myungsoo Joo [Corée du Sud] ; Ki-Tae Ha [Corée du Sud]Source :
- Biochemical and biophysical research communications [ 1090-2104 ] ; 2016.
Descripteurs français
- KwdFr :
- Acides sialiques (analyse), Acides sialiques (métabolisme), Animaux, Basse température, Glycoprotéine hémagglutinine du virus influenza (métabolisme), Grippe humaine (anatomopathologie), Grippe humaine (métabolisme), Grippe humaine (étiologie), Humains, Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (métabolisme), Infections à Orthomyxoviridae (étiologie), Liaison aux protéines, Lignée cellulaire, Mâle, Poumon (anatomopathologie), Poumon (métabolisme), Poumon (virologie), Souris de lignée C57BL, Sous-type H1N1 du virus de la grippe A (métabolisme), Stress physiologique.
- MESH :
- analyse : Acides sialiques.
- anatomopathologie : Grippe humaine, Infections à Orthomyxoviridae, Poumon.
- métabolisme : Acides sialiques, Glycoprotéine hémagglutinine du virus influenza, Grippe humaine, Infections à Orthomyxoviridae, Poumon, Sous-type H1N1 du virus de la grippe A.
- virologie : Poumon.
- étiologie : Grippe humaine, Infections à Orthomyxoviridae.
- Animaux, Basse température, Humains, Liaison aux protéines, Lignée cellulaire, Mâle, Souris de lignée C57BL, Stress physiologique.
English descriptors
- KwdEn :
- Animals, Cell Line, Cold Temperature, Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Humans, Influenza A Virus, H1N1 Subtype (metabolism), Influenza, Human (etiology), Influenza, Human (metabolism), Influenza, Human (pathology), Lung (metabolism), Lung (pathology), Lung (virology), Male, Mice, Inbred C57BL, Orthomyxoviridae Infections (etiology), Orthomyxoviridae Infections (metabolism), Orthomyxoviridae Infections (pathology), Protein Binding, Sialic Acids (analysis), Sialic Acids (metabolism), Stress, Physiological.
- MESH :
- chemical , analysis : Sialic Acids.
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus, Sialic Acids.
- etiology : Influenza, Human, Orthomyxoviridae Infections.
- metabolism : Influenza A Virus, H1N1 Subtype, Influenza, Human, Lung, Orthomyxoviridae Infections.
- pathology : Influenza, Human, Lung, Orthomyxoviridae Infections.
- virology : Lung.
- Animals, Cell Line, Cold Temperature, Humans, Male, Mice, Inbred C57BL, Protein Binding, Stress, Physiological.
Abstract
Ambient cold temperature, as an abiotic stress, regulates the survival, stability, transmission, and infection of pathogens. However, the effect of cold temperature on the host receptivity to the pathogens has not been fully studied. In this study, the expression of terminal α-2,3- and α-2,6-sialic acids were increased in murine lung tissues, especially bronchial epithelium, by exposure to cold condition. The expression of several sialyltransferases were also increased by exposure to cold temperature. Furthermore, in human bronchial epithelial BEAS-2B cells, the expressions of α-2,3- and α-2,6-sialic acids, and mRNA levels of sialyltransferases were increased in the low temperature condition at 33 °C. On the other hand, the treatment of Lith-Gly, a sialyltransferase inhibitor, blocked the cold-induced expression of sialic acids on surface of BEAS-2B cells. The binding of influenza H1N1 hemagglutinin (HA) toward BEAS-2B cells cultured at low temperature condition was increased, compared to 37 °C. In contrast, the cold-increased HA binding was blocked by treatment of lithocholicglycine and sialyl-N-acetyl-D-lactosamines harboring α-2,3- and α-2,6-sialyl motive. These results suggest that the host receptivity to virus at cold temperature results from the expressions of α-2,3- and α-2,6-sialic acids through the regulation of sialyltransferase expression.
DOI: 10.1016/j.bbrc.2016.05.020
PubMed: 27181350
Affiliations:
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Le document en format XML
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Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>School of Korean Medicine and Korean Medicine Research Center for Healthy Aging, Pusan National University, Yangsan, 50612</wicri:regionArea><wicri:noRegion>50612</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Hee Jung" sort="Choi, Hee Jung" uniqKey="Choi H" first="Hee-Jung" last="Choi">Hee-Jung Choi</name><affiliation wicri:level="1"><nlm:affiliation>School of Korean Medicine and Korean Medicine Research Center for Healthy Aging, Pusan National University, Yangsan, 50612, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>School of Korean Medicine and Korean Medicine Research Center for Healthy Aging, Pusan National University, Yangsan, 50612</wicri:regionArea><wicri:noRegion>50612</wicri:noRegion></affiliation></author><author><name sortKey="Park, Mi Ju" sort="Park, Mi Ju" uniqKey="Park M" first="Mi-Ju" last="Park">Mi-Ju Park</name><affiliation wicri:level="1"><nlm:affiliation>School of Korean Medicine and Korean Medicine Research Center for Healthy Aging, Pusan National University, Yangsan, 50612, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>School of Korean Medicine and Korean Medicine Research Center for Healthy Aging, Pusan National University, Yangsan, 50612</wicri:regionArea><wicri:noRegion>50612</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Hee Jin" sort="Choi, Hee Jin" uniqKey="Choi H" first="Hee-Jin" last="Choi">Hee-Jin Choi</name><affiliation wicri:level="1"><nlm:affiliation>School of Korean Medicine and Korean Medicine Research Center for Healthy Aging, Pusan National University, Yangsan, 50612, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>School of Korean Medicine and Korean Medicine Research Center for Healthy Aging, Pusan National University, 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Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Clinical Pathology, TaeKyeung University, Gyeongsan, 38547</wicri:regionArea><wicri:noRegion>38547</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Cheorl Ho" sort="Kim, Cheorl Ho" uniqKey="Kim C" first="Cheorl-Ho" last="Kim">Cheorl-Ho Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Science, Sungkyunkwan University, Suwon, Kyunggi-do 16419, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biological Science, Sungkyunkwan University, Suwon, Kyunggi-do 16419</wicri:regionArea><wicri:noRegion>Kyunggi-do 16419</wicri:noRegion></affiliation></author><author><name sortKey="Joo, Myungsoo" sort="Joo, Myungsoo" uniqKey="Joo M" first="Myungsoo" last="Joo">Myungsoo Joo</name><affiliation wicri:level="1"><nlm:affiliation>School of Korean Medicine and Korean Medicine Research Center for Healthy Aging, Pusan National University, Yangsan, 50612, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>School of Korean Medicine and Korean Medicine Research Center for Healthy Aging, Pusan National University, Yangsan, 50612</wicri:regionArea><wicri:noRegion>50612</wicri:noRegion></affiliation></author><author><name sortKey="Ha, Ki Tae" sort="Ha, Ki Tae" uniqKey="Ha K" first="Ki-Tae" last="Ha">Ki-Tae Ha</name><affiliation wicri:level="1"><nlm:affiliation>School of Korean Medicine and Korean Medicine Research Center for Healthy Aging, Pusan National University, Yangsan, 50612, Republic of Korea. Electronic address: hagis@pusan.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>School of Korean Medicine and Korean Medicine Research Center for Healthy Aging, Pusan National University, Yangsan, 50612</wicri:regionArea><wicri:noRegion>50612</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biochemical and biophysical research communications</title><idno type="eISSN">1090-2104</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Cold Temperature</term><term>Hemagglutinin Glycoproteins, Influenza Virus (metabolism)</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (metabolism)</term><term>Influenza, Human (etiology)</term><term>Influenza, Human (metabolism)</term><term>Influenza, Human (pathology)</term><term>Lung (metabolism)</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Male</term><term>Mice, Inbred C57BL</term><term>Orthomyxoviridae Infections (etiology)</term><term>Orthomyxoviridae Infections (metabolism)</term><term>Orthomyxoviridae Infections (pathology)</term><term>Protein Binding</term><term>Sialic Acids (analysis)</term><term>Sialic Acids (metabolism)</term><term>Stress, Physiological</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acides sialiques (analyse)</term><term>Acides sialiques (métabolisme)</term><term>Animaux</term><term>Basse température</term><term>Glycoprotéine hémagglutinine du virus influenza (métabolisme)</term><term>Grippe humaine (anatomopathologie)</term><term>Grippe humaine (métabolisme)</term><term>Grippe humaine (étiologie)</term><term>Humains</term><term>Infections à Orthomyxoviridae (anatomopathologie)</term><term>Infections à Orthomyxoviridae (métabolisme)</term><term>Infections à Orthomyxoviridae (étiologie)</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Mâle</term><term>Poumon (anatomopathologie)</term><term>Poumon (métabolisme)</term><term>Poumon (virologie)</term><term>Souris de lignée C57BL</term><term>Sous-type H1N1 du virus de la grippe A (métabolisme)</term><term>Stress physiologique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Sialic Acids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Sialic Acids</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Acides sialiques</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Grippe humaine</term><term>Infections à Orthomyxoviridae</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Influenza, Human</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza, Human</term><term>Lung</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acides sialiques</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Grippe humaine</term><term>Infections à Orthomyxoviridae</term><term>Poumon</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Influenza, Human</term><term>Lung</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Grippe humaine</term><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Cold Temperature</term><term>Humans</term><term>Male</term><term>Mice, Inbred C57BL</term><term>Protein Binding</term><term>Stress, Physiological</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Basse température</term><term>Humains</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Mâle</term><term>Souris de lignée C57BL</term><term>Stress physiologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ambient cold temperature, as an abiotic stress, regulates the survival, stability, transmission, and infection of pathogens. However, the effect of cold temperature on the host receptivity to the pathogens has not been fully studied. In this study, the expression of terminal α-2,3- and α-2,6-sialic acids were increased in murine lung tissues, especially bronchial epithelium, by exposure to cold condition. The expression of several sialyltransferases were also increased by exposure to cold temperature. Furthermore, in human bronchial epithelial BEAS-2B cells, the expressions of α-2,3- and α-2,6-sialic acids, and mRNA levels of sialyltransferases were increased in the low temperature condition at 33 °C. On the other hand, the treatment of Lith-Gly, a sialyltransferase inhibitor, blocked the cold-induced expression of sialic acids on surface of BEAS-2B cells. The binding of influenza H1N1 hemagglutinin (HA) toward BEAS-2B cells cultured at low temperature condition was increased, compared to 37 °C. In contrast, the cold-increased HA binding was blocked by treatment of lithocholicglycine and sialyl-N-acetyl-D-lactosamines harboring α-2,3- and α-2,6-sialyl motive. These results suggest that the host receptivity to virus at cold temperature results from the expressions of α-2,3- and α-2,6-sialic acids through the regulation of sialyltransferase expression.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement><orgName><li>Université nationale de Séoul</li></orgName></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Moon, Seong Cheol" sort="Moon, Seong Cheol" uniqKey="Moon S" first="Seong-Cheol" last="Moon">Seong-Cheol Moon</name></noRegion><name sortKey="Bae, Sung Jin" sort="Bae, Sung Jin" uniqKey="Bae S" first="Sung-Jin" last="Bae">Sung-Jin Bae</name><name sortKey="Choi, Hee Jin" sort="Choi, Hee Jin" uniqKey="Choi H" first="Hee-Jin" last="Choi">Hee-Jin Choi</name><name sortKey="Choi, Hee Jung" sort="Choi, Hee Jung" uniqKey="Choi H" first="Hee-Jung" last="Choi">Hee-Jung Choi</name><name sortKey="Chung, Tae Wook" sort="Chung, Tae Wook" uniqKey="Chung T" first="Tae-Wook" last="Chung">Tae-Wook Chung</name><name sortKey="Ha, Ki Tae" sort="Ha, Ki Tae" uniqKey="Ha K" first="Ki-Tae" last="Ha">Ki-Tae Ha</name><name sortKey="Joo, Myungsoo" sort="Joo, Myungsoo" uniqKey="Joo M" first="Myungsoo" last="Joo">Myungsoo Joo</name><name sortKey="Joo, Su Yeon" sort="Joo, Su Yeon" uniqKey="Joo S" first="Su-Yeon" last="Joo">Su-Yeon Joo</name><name sortKey="Kim, Cheorl Ho" sort="Kim, Cheorl Ho" uniqKey="Kim C" first="Cheorl-Ho" last="Kim">Cheorl-Ho Kim</name><name sortKey="Kim, Keuk Jun" sort="Kim, Keuk Jun" uniqKey="Kim K" first="Keuk-Jun" last="Kim">Keuk-Jun Kim</name><name sortKey="Park, Mi Ju" sort="Park, Mi Ju" uniqKey="Park M" first="Mi-Ju" last="Park">Mi-Ju Park</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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